Download PDF by Urs von Stockar (Editor), Luuk van der Wielen (Editor): Advances in Biochemical Engineering & Biotechnology, Volume

By Urs von Stockar (Editor), Luuk van der Wielen (Editor)

ISBN-10: 3540436308

ISBN-13: 9783540436300

Approach integration has been some of the most energetic examine fields in Biochemical Engineering during the last decade and it'll stay so if bioprocessing is to develop into extra rational, effective and effective. This quantity outlines what has been accomplished in recent times. Written by means of specialists who've made vital contributions to the eu technological know-how, starting place software on method Integration in Biochemical Engineering, the amount specializes in the growth made and the most important possibilities, and also at the barriers and the demanding situations in bioprocess integration that lie forward. the concept that of bioprocess integration is taken care of at quite a few degrees, together with integration on the molecular, organic, bioreactor and plant degrees, but in addition accounting for the mixing of separation and mass move operations and biology, fluid dynamics and body structure, in addition to uncomplicated technological know-how and approach know-how.

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The property can be compared in geometric similar vessels. For more details the reader is referred to the original paper by Jenne and Reuss [1]. Table 2. 15 28 S. Schmalzriedt et al. The Reynolds equations, the continuity equation, which is turned into an equation for pressure correction [10], and the transport equations for the turbulence quantities k and e, are integrated over the respective finite volume elements resulting from the discretization of the stirred tank domain. The convection and diffusion terms in the transport equations are approximated using the hybrid-scheme of Patankar [10].

15 28 S. Schmalzriedt et al. The Reynolds equations, the continuity equation, which is turned into an equation for pressure correction [10], and the transport equations for the turbulence quantities k and e, are integrated over the respective finite volume elements resulting from the discretization of the stirred tank domain. The convection and diffusion terms in the transport equations are approximated using the hybrid-scheme of Patankar [10]. 1). a b c Fig. 3a–c. 014 Integration of Physiology and Fluid Dynamics 29 So-called false-time-step relaxation is used to achieve stationarity.

5 With tm, 95 = time for 95% homogeneity. This result is in reasonable agreement with numbers reported in the literature (ntm = 35 [54] and ntm = 32 [55]). Despite this good agreement, the terminal mixing time itself does not provide a very informative measure of the mixing process. Because transient concentrations in all volume elements are available from the simulations, it is also possible to calculate the time course of inhomogeneity defined by Landau and Prochazka [56]: I (t ) = 1 n  Vi (ci (t ) – c • ) V (c • – c 0 ) (37) i=1 Figure 10 summarizes the transient homogeneity for three simulated tracer experiments differing in the position of the tracer input.

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Advances in Biochemical Engineering & Biotechnology, Volume 080: Process Integration in Biochemical Engineering by Urs von Stockar (Editor), Luuk van der Wielen (Editor)


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