Download e-book for iPad: Amyloid and Related Disorders: Surgical Pathology and by Maria M. Picken MD PhD FASN, Ahmet Dogan, Guillermo A.

By Maria M. Picken MD PhD FASN, Ahmet Dogan, Guillermo A. Herrera

ISBN-10: 3319192930

ISBN-13: 9783319192932

ISBN-10: 3319192949

ISBN-13: 9783319192949

The moment variation of this article offers an summary of the newest advancements during this region together with scientific presentation, etiology, pathogenesis, and differential prognosis. the reason for varied treatments, together with transplantation, is mentioned and tissue analysis (its pitfalls and methods for keeping off them) and laboratory help are incorporated. The involvement of all significant organ platforms together with renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central apprehensive process, smooth tissue, epidermis, lymph node/spleen and bone marrow pathology is usually covered.

Amyloid and similar problems, moment Edition could be valuable to really expert and basic pathologists in addition to cytopathologists. different doctors can also take advantage of this concise replace at the systemic amyloidoses.

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Extra info for Amyloid and Related Disorders: Surgical Pathology and Clinical Correlations

Sample text

Remarkably, several mutations in genes encoding APP or presenilins, members of the γ-secretases, can strongly favour the amyloidogenic proteolytic cleavage of APP and are hence associated with familial forms of the disease [20]. 4. Intrinsic instability There are a few proteins that are believed to display an intrinsic propensity to adopt more than one conformation, a feature strongly influenced by hydrophobicity, electric charge and secondary structure [5] and which might—in the long term—lead to amyloid formation.

2011;167:57–63. 88. Cohen AD, et al. Systemic AL amyloidosis due to non-Hodgkin’s lymphoma: an unusual clinicopathologic association. Br J Haematol. 2004;124:309–14. 89. Telio D, et al. Two distinct syndromes of lymphomaassociated AL amyloidosis: a case series and review of the literature. Am J Hematol. 2010;85:805–8. 90. Ikee R, Kobayashi S, Hemmi N, Suzuki S, Miura S. Amyloidosis associated with chronic lymphocytic leukemia. Amyloid. 2005;12:131–4. 91. Perfetti V, et al. AL amyloidosis. Characterization of amyloidogenic cells by anti-idiotypic monoclonal antibodies.

Circulation. 2001;104:1594–7. 75. Brenner DA, et al. Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress. Circ Res. 2004;94:1008–10. 76. Shi J, et al. Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38alpha MAPK pathway. Proc Natl Acad Sci USA. 2010;107:4188–93. 77. Silveira JR, et al. The most infectious prion protein particles. Nature. 2005;437:257–61. 78. Campioni S, et al.

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Amyloid and Related Disorders: Surgical Pathology and Clinical Correlations by Maria M. Picken MD PhD FASN, Ahmet Dogan, Guillermo A. Herrera


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