By Perkin G David
Any dialogue of the scientific features of Parkinson's sickness needs to keep in mind the inaccuracies of medical analysis. In a successive sequence of a hundred sufferers with a scientific analysis of Parkinson's disorder, in simple terms seventy six fulfilled the standards for analysis at autopsy exam. makes an attempt to tighten the diagnostic standards bring about elevated specificity yet with decreased sensitivity.In An Atlas of Parkinson's affliction and similar problems Dr. David Perkin has compiled a chain of photos highlighting quite a few features of Parkinson's illness and comparable motor problems. The ebook offers an invaluable pattern of scientific, investigative (CT, MRI, and puppy) and pathological photos with succinct descriptive textual content of the problems featured. nearly one-third of the cloth during this e-book is pathological, incorporating either macroscopic and microscopic sections. an additional zone of the cloth is represented via imaging, largely magnetic resonance imaging (MRI) and positron emission tomography (PET) scanning. the world of circulation problems has been fairly fruitful for puppy scanning, which delivers, with the advance of particular ligands for many of the receptor websites, to extra extend figuring out of the pathophysiological mechanisms of the stream problems. Reflecting the top criteria scientific images and imaging in addition to the prestigious author's specialist wisdom of the topic, Dr. Perkin's An Atlas of Parkinson's sickness and similar problems is the definitive and crucial medical reference in its box.
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Extra resources for An Atlas of Parkinson's Disease and Related Disorders (Encyclopedia of Visual Medicine Series)
11C-raclopride is a selective reversible antagonist of D2 receptors) Figure 33 Coronal section of brain from a patient with striatonigral degeneration showing symmetrical atrophy and discoloration of the putamen ©2004 CRC Press LLC Figure 34 Histology of striatonigral degeneration shows atrophy of the putamen with rarefaction and gliosis (H & E) Figure 35 Transverse section of midbrain in striatonigral degeneration shows pallor of the substantia nigra ©2004 CRC Press LLC Figure 36 Axial (upper) and coronal (lower) T2-weighted MRIs showing putaminal hypointensity (arrowed) in a patient with striatonigral degeneration ©2004 CRC Press LLC Figure 37 Coronal sections showing normal (upper) compared with atrophied (lower) basis pontis secondary to olivopontocerebellar atrophy in multiple system atrophy Figure 38 Histological sections of basis pontis (arrowed) show the normal complement of pontine neurons in a control subject (left) compared with neuronal depletion (right) in multiple system atrophy (H & Es) ©2004 CRC Press LLC Figure 39 Multiple system atrophy with olivopontocerebellar atrophy.
Evidence of Purkinje cell degeneration (right) with formation of axon torpedoes (white arrow) is seen in the molecular layer (H & Es) ©2004 CRC Press LLC Figure 40 Histological sections showing examples of oligodendroglial cytoplasmic inclusions in multiple system atrophy (H & Es) ©2004 CRC Press LLC Figure 41 Sagittal T1-weighted MRI showing pontine (black arrow) and cerebellar (white arrow) atrophy in a patient with olivopontocerebellar atrophy ©2004 CRC Press LLC Figure 42 T2-weighted MRI (upper) shows hyperintensity of the middle cerebellar peduncles and the cerebellum.
Debris and a few vascular channels can be seen (Luxol fast blue–H & E) Figure 24 CT of a patient with a Parkinsonian syndrome shows multiple lacunar infarcts ©2004 CRC Press LLC Figure 25 T1-weighted MRI showing multiple small hypointense foci in the putamen and caudate nuclei bilaterally. The patient had presented with a Parkinsonian state with, eventually, predominant axial features Figure 26 Coronal brain section (same patient as in Figure 25) showing numerous small lacunes in the heads of both caudate nuclei and in the anterior part of the putamen ©2004 CRC Press LLC Figure 27 Histological sections from Parkinson's disease with dementia showing cortical Lewy bodies stained with ubiquitin (immunochemistry preparation, left; silver impregnation, right) Figure 28 Histology showing a subthalamic neuron containing a globose neurofibrillary tangle in progressive supranuclear palsy (Bielschowsky silver impregnation) ©2004 CRC Press LLC A B C D Figure 29 In this patient with progressive supranuclear palsy, upward (A) and lateral gaze (B and C) are preserved whereas down gaze (D) is impaired ©2004 CRC Press LLC Figure 30 Attempted down gaze (left) shows improvement with the doll's-head maneuver (right) in this patient with progressive supranuclear palsy Figure 31 Sagittal T1-weighted MRI showing midbrain atrophy (arrowed) in progressive supranuclear palsy ©2004 CRC Press LLC Figure 32 11C-raclopride binding in a normal subject (left) compared with that in Parkinson's disease (middle) and in progressive supranuclear palsy (right).
An Atlas of Parkinson's Disease and Related Disorders (Encyclopedia of Visual Medicine Series) by Perkin G David