By Professor Klaus Kayser M.D., Ph.D. (auth.)
All illnesses regarding the lung are awarded in alphabetical order. every one is mentioned within the comparable method lower than the subheadings of definition, epidemiology, pathophysio- logy, medical analysis, radiology, gross and micro patho- logy, histomorphological descriptors, precise stains, corridor- mark of analysis and differential diagnosis.
"An encyclopedic number of phrases facing ailments and/or pathological stipulations of the breathing organs with the purpose to offer the reader fast information regarding the basic points. This encyclopedic resource might be suggested not just to pathologists but in addition to clinicians and practitioners confronted with pulmonary diseases." (Experimental and Toxicologic Pathology)
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Additional info for Analytical Lung Pathology
A mild inflammatory infiltration within the tumor mass and at its boundary is present in the majority of cases. An extracellular mucus production is infrequent, in contrast to PAS-positive granules within the cytoplasm of tumor cells. Bronchioloalveolar carcinoma shows two different growth beha30 viors: The majority of patients suffer from solid, central scarred tumors with "lined up" tumor cells along the interalveolar septula at the tumor boundary. Additional acinar appearance of tumor textures is frequent.
Prognosis: Involvement of the lung is usually not severe, and death occurs due to cardiac failure. Radiology: No specific manifestations are known. Pathology: Gross: No specific findings. Histology: Increased accumulation of glycogen in macrophages. It is unclear whether interstitial glycogen deposits exist. ~ Descriptors: Lung parenchyma with preserved structure: • macrophages (glycogen deposits) • Special stains: PAS, endogenous lectins. Hallmark of Diagnosis: Clinical history, intraalveolar accumulation of glycogen-laden macrophages, biochemical identification of acid maltase deficiency.
Radiology: Localized, circumscribed, dense infiltrates depending upon the degree of infection. Pathology: Gross: Circumscribed, yellowish-white nodules. Histology: Mixed cellular infiltrates with central necrosis and granulomatous organization including multinucleated giant cells similar to rheumatoid nodules. The organism can be recognized by the yeastlike colonies which consist of endosporulating sporangia. The oval cells contain vacuolated cytoplasm and small, dark nuclei. The hyaline walls of the sporangia stain positively with PAS, Gomori's methenamine silver stain (GMS), Gridley's stains.
Analytical Lung Pathology by Professor Klaus Kayser M.D., Ph.D. (auth.)