Download e-book for kindle: Animal Models of Human Disease, Volume 100 (Molecular by Min Kyung-Tai, Karen Chang

By Min Kyung-Tai, Karen Chang

ISBN-10: 0123848784

ISBN-13: 9780123848789

Animal experiments have contributed a lot to our realizing of mechanisms of sickness and are important for selecting new remedies. This quantity reports the most recent examine and advancements during this box. * Discusses new discoveries, techniques, and ideas * Contributions from top students and specialists * Reference advisor for researchers desirous about molecular biology and similar fields

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Additional resources for Animal Models of Human Disease, Volume 100 (Molecular Biology and Translational Science)

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In addition, branching morphogenesis of the Fgfr2cn prostates is significantly impaired, which can be characterized by deficient intraluminal infolding, and the luminal epithelial cells are not well polarized. In contrast to wild-type prostates, maintenance of mature Fgfr2cn prostates is not strictly androgen dependent. No significant prostatic atrophy is observed even at 2 weeks after castration in adult Fgfr2cn mice. Similarly, 36 FEN WANG androgen replenishment also fails to induce cell proliferation in the Fgfr2cn prostates.

Mutations in p53 that cause changes in the complex network of molecular events are often found to be associated with prostate tumor initiation, progression, metastasis, and androgen-deprivation resistance. Acute Pten inactivation induces growth arrest through the p53-dependent cellular senescence pathway. This Pten deficiency-induced senescence can be fully rescued by the combined loss of p53. 87 Compared to the prostate of nontransgenic littermates, the transgenic prostate undergoes less apoptosis after castration, suggesting compromised apoptotic potential in the transgenic prostates.

Most adenocarcinomas in the C3(1)/SV40 T mice are locally invasive. The main disadvantage of the C3(1)/ SV40 T model is that the transgene is also expressed in other tissues including MOUSE MODELS OF HUMAN PROSTATE CANCER 15 mammary, thyroid, and salivary glands. Nevertheless, the progression of PIN to invasive prostate carcinoma in the C3(1)/SV40 T mice appears to be similar to the process occurred in humans. 27 Transgene expression is initiated between 7 and 8 weeks of age in all prostatic lobes.

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Animal Models of Human Disease, Volume 100 (Molecular Biology and Translational Science) by Min Kyung-Tai, Karen Chang

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