By B. Frisch, R. Bartl (auth.)
Examination of the bone marrow has continuously been, and to-date recommendations whose program will unquestionably to a wide quantity nonetheless is, in the area of the haema bring up sooner or later. tologist. it's because smears of bone marrow aspirates After long discussions and enquiries, the belief including peripheral blood motion pictures and result of different was once reached that the magnifications of many of the checks and investigations supplied the data on which illustrations should be passed over with no detracting from the usefulness of the Atlas. The magnifications used are the scientific analysis was once established. lately, the common availability of either enhanced indicated in Fig. 1.25. furthermore, now not each element specif biopsy needles and methods for processing has significantly ically indicated in a determine or its legend is inevitably elevated the variety of sometimes taken bone biopsies pointed out within the textual content; and sometimes a variety of observations and put the exam of bone marrow biopsy is illustrated and in those circumstances the legends are self sectiors additionally within the box of histopathology - in order that explanatory. this Atlas is likely one of the present Histopathology sequence. This Atlas is directed to haematologists and to histo hence, the haematologist and the histopathologist pathologists and to a person attracted to the research now supplement one another within the interpretation of bone and figuring out of the human bone marrow. marrow smears, imprints and sections, hence using all to be had details and services to reach at a diagnosis.
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The chronic type is either congenital - the Blackfan-Diamond syndrome - or acquired, with selective inhibition of erythropoiesis. 22). There may be a patchy, localized replacement by fat cells, together with areas of normal cellularity; but at high power these contain only an isolated erythroblast or two, with no erythroid islands. Megakaryocytes and granulopoietic precursors appear within normal limits. Iron-containing stromal cells are increased, as are macrophages containing cellular debris, and mast and plasma cells; aggregates of lymphoid cells may be present.
10 Section of bone biopsy of patient with metastatic cancer, but no Irlvolvement in the biopsy, megakaryocytic hyperplasia Fig. 11 Section of bone biopsy of patient with malignant melanoma, hyperplasia of megakaryocytes near the metastases. 14 thrombocytosis Fig. 12 Sections of bone biopsies of patients with reactive Megakaryocytes range In size from small to very larg(' 50 HYPERPLASIAS Fig. 13 Configuration of megakaryocyte nuclei resembles that in myeloproliferative disorders. Note also range in size and megakaryoblast Fig.
P.. Stockinger. H. Aberer. w.. liszka. K. Lutz. D. and Knapp. W (1984). M 2. a novel myelomonocytic cell 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. surface antigen and Its distribution on leukemic cells. Int. J Cancer. 617 Griffin. J. D .. Ritz. J. Nadler. M. and Schlossman. S F. (1981). Expression of myeloid differentiation antigens on normal and mallg· nant myeloid cells. J Clin. Invest.. 68. 932 Knapp. w.. Majdic. 0 .. Holter. w.. Stockinger. H. and Koller. U (1985). Oberlegungen zur therapeutischen Verwendung monoklonaler Antikbrper.
Atlas of Bone Marrow Pathology by B. Frisch, R. Bartl (auth.)